One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles

作者： Cheng S. Jin1,2,3, Jonathan F. Lovell4, Gang Zheng1,2,3 1Department of Pharmaceutical Sciences,University of Toronto, 2The Institute of Biomaterials and Biomedical Engineering,University of Toronto, 3Ontario Cancer Institute,Campbell Family Institute For Cancer Research and Techna Institute, 4Department of Biomedical Engineering,University at Buffalo, The State University of New York

简介：

Overview

This study presents the development of porphysomes, novel intrinsic multifunctional nanovesicles with unique photothermal properties. The efficacy of these nanovesicles as photothermal therapy agents was evaluated in a xenograft tumor model.

Key Study Components

Area of Science

• Nanotechnology
• Oncology
• Photothermal therapy

Background

• Porphysomes are nanoparticles that exhibit structure-dependent fluorescence self-quenching.
• They are designed to enhance photothermal therapy for tumor treatment.
• High pressure extrusion is used for their formulation.
• Previous studies have indicated their potential in multimodal imaging and image-guided therapy.

Purpose of Study

• To synthesize porphysomes using high pressure extrusion.
• To assess the effectiveness of porphysomes in photothermal therapy for tumors.
• To evaluate their biocompatibility and drug loading capacity.

Methods Used

• Conjugation of pyro four by alpha to phospholipid to form pyro feel four by lipid.
• Self-assembly of pyro four by lipids into porphysomes via high pressure extrusion.
• Characterization of porphysomes for quality control.
• Injection of porphysomes into subcutaneous tumor-bearing animals followed by laser irradiation.

Main Results

• Porphysomes demonstrated high homogeneity and quenched fluorescence.
• They showed a 100% survival rate in the in vivo animal study.
• Porphysomes are effective photothermal agents.
• They maintain the drug loading capacity and biocompatibility of conventional liposomes.

Conclusions

• Porphysomes are the first organic nanoparticles to enhance photothermal therapy efficiently.
• The technique has implications for tumor therapy and diagnosis.
• Further research could expand their applications in clinical settings.

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