Small animal imaging techniques allow serial diagnostic examinations and therapeutic interventions in vivo. Recently, the scope of applications has significantly widened and currently includes assessment of colonic tumor development, wound healing and monitoring of inflammation. This protocol illustrates these diverse potential applications of murine endoscopy.
In this video, a variety of applications from neuron endoscopy will be presented in the first application. How to use the endoscope to score disease severity in a mouse model of colitis will be shown in the second application. The use of endoscopy to monitor mucosal wound healing in vivo will be demonstrated in the last application.
The use of fluorescence endoscopy to detect intestinal tumors and the technique to intra mucosally inject agents will be presented ultimately intestinal wound healing, inflammation, and cancer. Agenesis can be assessed based on the findings of the endoscopic analysis. The main advantage of this technique over existing methods like histological analysis of experimental colitis, is that with this technique, you can perform intra individual follow-up examinations and repetitively assess mucosal alterations.
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