Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

作者： Carlos Trenado1, Saskia Elben2, David Petri2, Jan Hirschmann2, Stefan J. Groiss1,2, Jan Vesper3, Alfons Schnitzler1,2, Lars Wojtecki1,2 1Institute of Clinical Neuroscience and Medical Psychology,Medical Faculty, Heinrich-Heine-University, 2Department of Neurology, Center for Movement Disorders and Neuromodulation,University Clinic Düsseldorf, 3Department of Neurosurgery, Functional Neurosurgery and Stereotaxy, Center for Movement Disorders and Neuromodulation,University Clinic Düsseldorf

简介：

Overview

This protocol assesses cognitive and emotional functions in the basal ganglia through simultaneous neurophysiological recordings of local field potentials and EEG. It exemplifies the use of speech stimuli with emotional connotation and the Flanker task for cognitive control.

Key Study Components

Area of Science

• Neuroscience
• Neurophysiology
• Cognitive Psychology

Background

• Understanding brain activity patterns is crucial for deciphering brain functions.
• Deep brain structures are often less accessible for study.
• Simultaneous recordings from deep and surface neuronal sources can provide valuable insights.
• This method is particularly useful in patients with movement disorders and disorders of consciousness.

Purpose of Study

• To assess the interaction of cognitive and emotional functions in the brain.
• To explore the relationship between brain activity and function.
• To utilize deep brain stimulation frameworks for real-time data extraction.

Methods Used

• Simultaneous recording of local field potentials and EEG.
• Application of cognitive tasks such as the Flanker task.
• Use of emotional speech paradigms for analysis.
• Focus on patients with specific neurological conditions.

Main Results

• Insights into the cognitive-emotional functions of the basal ganglia.
• Demonstration of the relationship between deep brain activity and cognitive tasks.
• Identification of brain activity patterns during emotional stimuli processing.
• Contribution to understanding neurophysiological mechanisms in humans.

Conclusions

• This method enhances our understanding of brain functions.
• It provides a framework for studying deep brain areas in real-time.
• The findings have implications for both cognitive and emotional neuroscience.

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