Biodegradable Magnesium Stent Treatment of Saccular Aneurysms in a Rat Model – Introduction of the Surgical Technique

作者： Edin Nevzati1,2, Jeannine Rey2, Daniel Coluccia1,2, Donato D'Alonzo1,2, Basil Grüter1,2, Luca Remonda3, Javier Fandino1,2, Serge Marbacher1,2 1Department of Neurosurgery,Kantonsspital Aarau, 2Neuro Lab, Research Group for Experimental Neurosurgery and Neurocritical Care, Department of Intensive Care Medicine,University Hospital and University of Bern, 3Division of Neuroradiology, Department of Radiology,Kantonsspital Aarau

简介：

Overview

This study presents a standardized surgical technique for stent-assisted embolization of saccular aneurysms in a rat model. The method aims to enhance the safety and reproducibility of experimental procedures related to intracranial aneurysm treatment.

Key Study Components

Area of Science

• Neurosurgery
• Neuroradiology
• Biomedical Engineering

Background

• Endovascular occlusion of intracranial aneurysms is a critical area of research.
• Novel embolization materials require reliable animal models for testing.
• Standardized techniques can improve the validity of experimental results.
• Low morbidity and mortality rates are essential for ethical research practices.

Purpose of Study

• To develop a safe and standardized method for occluding saccular sidewall aneurysms.
• To facilitate the study of new stent devices and their healing mechanisms.
• To address key questions in neurosurgery and neuroradiology.

Methods Used

• Use of biodegradable magnesium stents for embolization.
• Procedure performed under general anesthesia.
• Open abdomen technique for access to the aneurysm site.
• Standardized surgical steps to ensure reproducibility.

Main Results

• The technique demonstrated low morbidity and mortality rates.
• High reproducibility was achieved across trials.
• Potential for further research into stent and flow diverter devices.
• Contributes to the understanding of aneurysm healing processes.

Conclusions

• This method provides a reliable model for testing new embolization materials.
• Standardization enhances the credibility of experimental findings.
• Future studies can build on this technique to explore various stent designs.

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