Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo

作者： Maxime Leblanc Latour1, Maryam Tarar2, Ryan J. Hickey1, Charles M. Cuerrier1, Isabelle Catelas3,4,5, Andrew E. Pelling1,2,6,7 1Department of Physics,University of Ottawa, 2Department of Biology,University of Ottawa, 3Department of Mechanical Engineering,University of Ottawa, 4Department of Surgery,University of Ottawa, 5Department of Biochemistry, Microbiology and Immunology,University of Ottawa, 6Institute for Science, Society and Policy,University of Ottawa, 7SymbioticA, School of Human Sciences,University of Western Australia

简介：

Overview

This study evaluates the potential of apple-derived cellulose scaffolds for bone tissue engineering, focusing on their mechanical properties in vitro and in vivo. It addresses the osteogenic potentials, cell invasion support, and mineralization capabilities of these scaffolds.

Key Study Components

Area of Science

• Bone tissue engineering
• Biomaterials
• Cellulose scaffolds

Background

• Plant-based biomaterials are being explored for tissue reconstruction.
• Cellulose scaffolds can be shaped and modified for desired characteristics.
• Functionalization techniques enhance scaffold effectiveness.
• Limited investigation exists on the mechanical properties of apple-derived cellulose.

Purpose of Study

• To evaluate the mechanical properties of apple-derived cellulose scaffolds.
• To assess their osteogenic potential and support for cell invasion.
• To investigate their mineralization capabilities.

Methods Used

• Decellularization of plant-based biomaterials.
• Physical characterization and imaging techniques.
• In vivo implantation of scaffolds.
• Cell seeding and differentiation methods.

Main Results

• Apple-derived cellulose scaffolds demonstrated promising mechanical properties.
• Scaffolds supported cell invasion and mineralization effectively.
• Research highlights the need for further investigation into their mechanical characteristics.
• Functionalization techniques improved scaffold performance.

Conclusions

• Apple-derived cellulose scaffolds are viable for bone tissue engineering.
• Further studies are needed to fully understand their mechanical properties.
• The research contributes to the field of biomaterials for tissue reconstruction.

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